ÉLPIS – Bioengineering of biomimetic bone models for the development of anti-tumour and regenerative therapies

One of the greatest challenges in the design of bone implants for tissue regeneration is ensuring that the cells within the structure receive nutrients and oxygen efficiently. Without an adequate transport network, the cells die and the implant fails biologically. Nature has been solving this problem for millions of years. Leaves, corals, bones, lungs, roots and vascular systems have developed highly efficient strategies for transporting fluids and nutrients through complex structures, minimising pressure drops, reducing turbulence and maximising coverage with the minimum amount of material.
Within the context of the ÉLPIS project, the design aims to explore the forms of these biological systems responsible for the flow and transport of nutrients in nature, in order to translate them into knowledge that enables the development of more effective three-dimensional scaffolds for bone tissue regeneration.

 

Start/end date Jan 2026 — Dec 2028

Lead institution

CENTRO2030-2024-76 - SACCCT - Programas Integrados de IC&DT, Portugal 2023, Cofunded by EU

Funding amount € 931 399

Project code CENTRO2030-FEDER-02616100